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Analytical Chemistry

X-ray Diffraction

Definition and meaning of X-ray Diffraction in chemistry.

X-ray diffraction is a powerful analytical technique used to determine the atomic and molecular structure of a crystal. It relies on the elastic scattering of X-ray photons by the electrons in the atoms comprising the sample.

In more detail

When a beam of X-rays strikes a crystalline material, the regularly spaced atoms act as a three-dimensional diffraction grating. This causes the X-rays to scatter in specific directions according to Bragg's Law. By measuring the angles and intensities of these scattered beams, scientists can construct a three-dimensional picture of the electron density within the crystal. This electron density map reveals the exact positions of the atoms, their chemical bonds, and various other structural details.

Key facts

FieldAnalytical Chemistry
Key equationBragg's Law
Primary useDetermining crystal structures
Example

X-ray diffraction was famously used by Rosalind Franklin to capture images of DNA, which proved crucial for identifying its double helix structure.

Frequently asked questions

Can X-ray diffraction be used on non-crystalline samples?

While standard X-ray crystallography requires ordered crystals, powder X-ray diffraction can be used to analyze polycrystalline materials and identify phase composition.

Why are X-rays used instead of visible light?

The wavelength of X-rays is roughly on the same scale as the distances between atoms in a crystal, which is necessary for diffraction to occur.